Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 4/20 | 0.39 |
| ▸ | VEGFA | P15692 | 3/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405092 | 0.83 | EGLN1 (0.40) | CYP11B2EGLN1ERN1FLT1VEGFA | |
| SCHEMBL22462719 | 0.77 | EGLN1 (0.60) | EGLN1IKBKBFLT1VEGFAMKNK1 | |
| SCHEMBL28778074 | 0.76 | EGLN1 (0.43) | EGLN1FLT1VEGFAEGLN3 | |
| SCHEMBL28778073 | 0.75 | GSK3B (0.40) | CYP11B2IKBKBCHUKERN1MKNK1 | |
| SCHEMBL14152807 | 0.74 | EGLN1 (0.62) | EGLN1FLT1VEGFALRRK2EGLN3 | |
| SCHEMBL1923191 | 0.74 | EGLN1 (0.73) | EGLN1FLT1VEGFAEGLN3 | |
| SCHEMBL1055362 | 0.74 | SPR (0.44) | CHUKMKNK1MKNK2 | |
| SCHEMBL27772404 | 0.74 | KMT2A (0.38) | EGLN1FLT1VEGFA | |
| SCHEMBL15641357 | 0.73 | EGLN1 (0.61) | EGLN1FLT1VEGFALRRK2EGLN3 | |
| SCHEMBL3031409 | 0.73 | EGLN1 (0.63) | EGLN1IKBKBFLT1VEGFAEGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357911-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3323807-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | Akebia Therapeutics, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |