Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18903799 | 0.71 | MAPK10 (0.40) | HSP90AA1HSD17B10POLBGAAKDM4E | |
| SCHEMBL18903831 | 0.66 | NISCH (0.34) | POLBMAPT | |
| SCHEMBL15037590 | 0.66 | HSP90AA1 (0.33) | HSP90AA1CYP19A1TBXAS1 | |
| SCHEMBL449725 | 0.61 | — | — | |
| SCHEMBL21025349 | 0.60 | PARP10 (0.46) | KDM4E | |
| SCHEMBL583280 | 0.58 | — | — | |
| SCHEMBL3129135 | 0.58 | HSD17B10 (0.39) | HSP90AA1HSD17B10POLBGAAKDM4E | |
| SCHEMBL15395750 | 0.58 | HSP90AA1 (0.38) | HSP90AA1HSD17B10POLBGAAKDM4E | |
| SCHEMBL13090140 | 0.58 | MAPT (0.39) | HSP90AA1HSD17B10POLBGAAKDM4E | |
| SCHEMBL333300 | 0.58 | MAPT (0.42) | HSP90AA1HSD17B10POLBGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323821-A1 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS | Pfizer Inc (US) | 2018-05-23 | — | — | EP | disclosed |