Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.70 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016472 | 1.00 | HCRTR1 (0.70) | HCRTR1HCRTR2NPC1RAB9AMEN1 | |
| SCHEMBL13139077 | 0.91 | HCRTR1 (0.75) | HCRTR1HCRTR2NPC1RAB9AMEN1 | |
| SCHEMBL13139074 | 0.89 | HCRTR1 (0.84) | HCRTR1HCRTR2NPC1RAB9AMEN1 | |
| SCHEMBL13139081 | 0.87 | HCRTR1 (0.70) | HCRTR1HCRTR2NPC1RAB9AMEN1 | |
| SCHEMBL13139076 | 0.87 | HCRTR1 (0.70) | HCRTR1HCRTR2NPC1RAB9AMEN1 | |
| SCHEMBL6919067 | 0.86 | HCRTR1 (0.69) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL2014960 | 0.86 | HCRTR1 (0.69) | HCRTR1HCRTR2NPC1RAB9APADI4 | |
| SCHEMBL13139060 | 0.85 | HCRTR1 (0.77) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL2010990 | 0.84 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AMEN1 | |
| SCHEMBL2011939 | 0.84 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |