Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 6/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 5/20 | 0.38 |
| ▸ | PIM1 | P11309 | 4/20 | 0.38 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162792 | 0.81 | DYRK1A (0.44) | DYRK1ADYRK1BDYRK2PIM1CDK9 | |
| SCHEMBL20173289 | 0.81 | DYRK1A (0.44) | DYRK1ADYRK1BDYRK2PIM1CDK9 | |
| SCHEMBL20162791 | 0.81 | DYRK1A (0.44) | DYRK1ADYRK1BDYRK2PIM1CDK9 | |
| SCHEMBL20162986 | 0.79 | DYRK1A (0.49) | DYRK1ADYRK1BDYRK2PIM1CDK9 | |
| SCHEMBL20508806 | 0.63 | DYRK1A (0.66) | DYRK1ADYRK1BDYRK2PIM1CDK9 | |
| SCHEMBL3787081 | 0.62 | SRC (0.50) | DYRK1ADYRK1BPIM1CDK9LRRK2 | |
| SCHEMBL10649970 | 0.61 | NPC1 (0.42) | MAP4K4ALOX5 | |
| SCHEMBL24962591 | 0.59 | IKBKB (0.41) | CDK1GSK3AGSK3BCDK5 | |
| SCHEMBL20182173 | 0.59 | PDK2 (0.45) | DYRK1ADYRK1BDYRK2PIM1CDK9 | |
| SCHEMBL10307717 | 0.58 | DYRK1A (0.38) | DYRK1ADYRK1BDYRK2PIM1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200017512-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | PFIZER INC. | 2020-01-16 | — | — | US | disclosed |
| US-10301315-B2 | Pyrrolopyrimidines as CFTR potentiators | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2019-05-28 | — | — | US | disclosed |
| US-20180141954-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. (US) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200017512-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CFTR, P2RX1, P2RX5 | DYRK1A 942/4885DYRK1B 988/4885DYRK2 2061/4885 |
| US-10301315-B2 | Pyrrolopyrimidines as CFTR potentiators | CFTR, P2RX1, P2RX5 | DYRK1A 902/4885DYRK1B 901/4885DYRK2 2035/4885 |
| US-20180141954-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CFTR, P2RX1, P2RX5 | DYRK1A 902/4885DYRK1B 901/4885DYRK2 2035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.