Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.73 |
| ▸ | PARP1 | P09874 | 5/20 | 0.63 |
| ▸ | COMT | P21964 | 2/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28723725 | 0.85 | KDM4E (1.00) | KDM4EPARP1COMTMMP2CHRM1 | |
| SCHEMBL1787225 | 0.81 | KDM4E (1.00) | KDM4EPARP1COMTMMP2CHRM1 | |
| SCHEMBL16509930 | 0.81 | CCR1 (0.59) | KDM4EPARP1PDGFRBPDGFRANPC1 | |
| Hydrochloric Acid SCHEMBL9333864 | 0.80 | KDM4E (0.96) | KDM4EPARP1COMTMMP2CHRM1 | |
| SCHEMBL27824094 | 0.80 | KDM4E (0.96) | KDM4EPARP1COMTMMP2CHRM1 | |
| SCHEMBL20176009 | 0.77 | KDM4E (0.62) | KDM4ECOMTMMP2CHRM1TSHR | |
| SCHEMBL18015542 | 0.75 | KDM4E (0.71) | KDM4EPARP1COMTMMP2CHRM1 | |
| SCHEMBL21952785 | 0.75 | KDM4E (0.64) | KDM4EPARP1COMTMMP2CHRM1 | |
| SCHEMBL13706265 | 0.74 | PARP1 (0.52) | KDM4EPARP1TSHRPDGFRBPDGFRA | |
| Jineol SCHEMBL29696064 | 0.73 | KDM4E (0.67) | KDM4ECOMTMMP2CHRM1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141911-A1 | Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease | NORTHEASTERN UNIVERSITY | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141911-A1 | Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease | MAPT, PSEN1, PSEN2 | KDM4E 3865/4885PARP1 2886/4885COMT 222/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.