Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 1.00 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.62 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.62 |
| ▸ | CCR1 | P32246 | 2/20 | 0.61 |
| ▸ | CCR5 | P51681 | 2/20 | 0.61 |
| ▸ | CCR8 | P51685 | 2/20 | 0.61 |
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | METAP2 | P50579 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | COMT | P21964 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9333864 | 0.98 | KDM4E (0.96) | KDM4EPSMD14COPS5CCR1CCR5 | |
| SCHEMBL27824094 | 0.98 | KDM4E (0.96) | KDM4EPSMD14COPS5CCR1CCR5 | |
| SCHEMBL20176003 | 0.81 | KDM4E (0.73) | KDM4EPSMD14COPS5PARP1METAP2 | |
| Jineol SCHEMBL29696064 | 0.80 | KDM4E (0.67) | KDM4EMETAP2MMP2CHRM1TSHR | |
| Jineol SCHEMBL4213727 | 0.80 | KDM4E (0.67) | KDM4EMETAP2MMP2CHRM1TSHR | |
| SCHEMBL7376462 | 0.80 | PSMD14 (0.67) | KDM4EPSMD14COPS5CCR1CCR5 | |
| SCHEMBL301595 | 0.79 | KDM4E (0.62) | KDM4EPSMD14COPS5CCR1CCR5 | |
| SCHEMBL2850764 | 0.78 | PSMD14 (0.65) | KDM4EPSMD14COPS5CCR1CCR5 | |
| Jineol SCHEMBL28133873 | 0.78 | KDM4E (0.65) | KDM4EMETAP2MMP2CHRM1TSHR | |
| SCHEMBL9645971 | 0.78 | KDM4E (1.00) | KDM4EPSMD14COPS5METAP2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117534809-A | Antibacterial aqueous polyurethane resin and preparation method and application thereof | 上海华峰新材料研发科技有限公司 | 2024-02-09 | — | — | CN | claimed |
| CN-116851037-A | Preparation method and application of hydroxyquinoline coordinated catalyst and compound | 上海元革新材料科技有限公司 | 2023-10-10 | — | — | CN | claimed |
| US-5614635-A | Method for the preparation of pyridine-2,3-dicarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1997-03-25 | — | — | US | claimed |
| EP-0331899-B1 | A method for the sequential oxidation of substituted-8-hydroxy-quinolines to produce substituted-pyridine-2,3-dicarboxylic acids | AMERICAN CYANAMID CO (US) | 1994-04-27 | — | — | EP | claimed |
| EP-0259687-B1 | METHOD FOR THE PREPARATION OF PYRIDINE-2,3-DICARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1991-07-03 | — | — | EP | claimed |
| EP-0331899-A2 | A method for the sequential oxidation of substituted-8-hydroxy-quinolines to produce substituted-pyridine-2,3-dicarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-09-13 | — | — | EP | claimed |
| US-4816588-A | OXIDATION OF 8-SUBSTITUTED QUINOLINES | AMERICAN CYANAMID COMPANY (US) | 1989-03-28 | — | — | US | claimed |
| EP-0259687-A2 | Method for the preparation of pyridine-2,3-dicarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1988-03-16 | — | — | EP | claimed |
| JP-6211794-A | — | — | None | — | — | JP | disclosed |
| EP-4623914-A1 | USE OF 8-HYDROXYQUINOLINE DERIVATIVE | Jiangsu Yahong Meditech Co., Ltd. (CN) | 2025-10-01 | — | — | EP | disclosed |
| CN-120035438-A | Use of 8-hydroxyquinoline derivatives | 江苏亚虹医药科技股份有限公司 | 2025-05-23 | — | — | CN | disclosed |
| CN-119390735-A | Hydroxyquinoline coordinated catalyst, preparation method, composite catalyst and application | 上海元革新材料科技有限公司 | 2025-02-07 | — | — | CN | disclosed |
| US-20240246916-A1 | 7-NITRO-8-HYDROXYQUINOLINE DERIVATIVES, PREPARATION METHOD THEREFORE AND MEDICAL USE THEREOF | JIANGSU YAHONG MEDITECH CO., LTD. (CN) | 2024-07-25 | — | — | US | disclosed |
| WO-2024109684-A1 | USE OF 8-HYDROXYQUINOLINE DERIVATIVE | 江苏亚虹医药科技股份有限公司 | 2024-05-30 | — | — | WO | disclosed |
| EP-0247277-B1 | PROCESS FOR THE PREPARATION OF 5-ALKYLQUINOLINIC ACIDS AND MEANS FOR CARRYING OUT THIS PROCESS | RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) | 1991-09-11 | — | — | EP | disclosed |
| EP-0259687-B1 | METHOD FOR THE PREPARATION OF PYRIDINE-2,3-DICARBOXYLIC ACIDS | AMERICAN CYANAMID COMPANY (US) | 1991-07-03 | — | — | EP | disclosed |
| EP-0331899-A2 | A method for the sequential oxidation of substituted-8-hydroxy-quinolines to produce substituted-pyridine-2,3-dicarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1989-09-13 | — | — | EP | disclosed |
| US-4816588-A | OXIDATION OF 8-SUBSTITUTED QUINOLINES | AMERICAN CYANAMID COMPANY (US) | 1989-03-28 | — | — | US | disclosed |
| EP-0259687-A2 | Method for the preparation of pyridine-2,3-dicarboxylic acids | AMERICAN CYANAMID COMPANY (US) | 1988-03-16 | — | — | EP | disclosed |
| EP-0247277-A2 | Process for the preparation of 5-alkylquinolinic acids and means for carrying out this process | RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) | 1987-12-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240246916-A1 | 7-NITRO-8-HYDROXYQUINOLINE DERIVATIVES, PREPARATION METHOD THEREFORE AND MEDICAL USE THEREOF | CYP3A7, UGT1A7, UGT2B7 | KDM4E 2921/4885PSMD14 1363/4885COPS5 1366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.