Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.58 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20176007 | 0.85 | PDGFRB (0.56) | PDGFRBPDGFRACYP19A1MAOAMAOB | |
| SCHEMBL6537874 | 0.80 | PARP1 (0.61) | PDGFRBPDGFRAALDH1A1KDM4EHPGD | |
| SCHEMBL6538221 | 0.75 | KDM4E (0.65) | PDGFRBPDGFRAKDM4EPARP1 | |
| SCHEMBL3164863 | 0.74 | PDGFRB (1.00) | PDGFRBPDGFRARELAALDH1A1KDM4E | |
| SCHEMBL3164867 | 0.74 | PDGFRB (1.00) | PDGFRBPDGFRARELAALDH1A1KDM4E | |
| SCHEMBL6501543 | 0.72 | NPC1 (0.57) | RELAGRM4ALDH1A1KDM4EHPGD | |
| SCHEMBL16880578 | 0.71 | PARP1 (0.44) | KDM4EPARP1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25181914 | 0.71 | PDGFRB (0.46) | PDGFRBPDGFRACYP19A1MAOAMAOB | |
| SCHEMBL26964134 | 0.71 | PARP1 (0.44) | KDM4EPARP1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1056354 | 0.71 | PDGFRB (0.54) | PDGFRBPDGFRAGRM4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180141911-A1 | Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease | NORTHEASTERN UNIVERSITY | 2018-05-24 | — | — | US | disclosed |
| US-20180141911-A1 | Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease | NORTHEASTERN UNIVERSITY | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141911-A1 | Quinoline Derivatives for Diagnosis and Treatment of Alzheimer's Disease | MAPT, PSEN1, PSEN2 | PDGFRB 4510/4885PDGFRA 4413/4885CYP19A1 3982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.