SCHEMBL6537874

SCHEMBL6537874

C=Cc1cnc2c(N)cccc2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 4/20 0.61
KDM4E B2RXH2 5/20 0.34
PSMD14 O00487 2/20 0.34
COPS5 Q92905 2/20 0.34
TDP1 Q9NUW8 2/20 0.34
PDGFRB P09619 1/20 0.34
PDGFRA P16234 1/20 0.34
LMNA P02545 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
PDE10A Q9Y233 2/20 0.33
STAMBP O95630 1/20 0.33
HTR3A P46098 1/20 0.33
NPC1 O15118 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GLA P06280 1/20 0.33
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20176006 0.80 PDGFRB (0.58) PARP1KDM4EPDGFRBPDGFRACYP3A4
SCHEMBL29250224 0.79 PARP1 (0.56) PARP1KDM4ETDP1PDGFRBPDGFRA
SCHEMBL19021469 0.77 PARP1 (0.58) PARP1KDM4EPSMD14COPS5TDP1
Formamide SCHEMBL9732098 0.76 PARP1 (0.62) PARP1KDM4ELMNAALDH1A1KMT2A
SCHEMBL30340529 0.76 PARP1 (0.50) PARP1
SCHEMBL6538201 0.74 PARP1 (0.56) PARP1KDM4ETDP1LMNACYP1A2
SCHEMBL16880578 0.74 PARP1 (0.44) PARP1KDM4EPSMD14COPS5TDP1
SCHEMBL26964134 0.73 PARP1 (0.44) PARP1KDM4EPSMD14COPS5TDP1
SCHEMBL10321093 0.73 BACE1 (0.39) PARP1KDM4EPSMD14COPS5TDP1
SCHEMBL31588980 0.73 KDM4E (0.37) PARP1KDM4EPSMD14COPS5TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876345-B1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO (JP) 2004-08-18 EP disclosed
US-6008230-A TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1999-12-28 US disclosed
EP-0876345-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-11-11 EP disclosed
WO-1997014681-A1 HETEROCYCLIC COMPOUNDS AS H+-ATPASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-04-24 WO disclosed