Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 5/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.49 |
| ▸ | NPBWR1 | P48145 | 8/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | PKLR | P30613 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22139429 | 0.80 | NPBWR1 (0.48) | PDE1APDE1BPDE1CNPBWR1PKM | |
| SCHEMBL22913090 | 0.80 | NPBWR1 (0.51) | PDE1APDE1BPDE1CNPBWR1PKM | |
| SCHEMBL22912921 | 0.80 | PDE1B (0.49) | PDE1APDE1BPDE1CNPBWR1PKM | |
| SCHEMBL21608784 | 0.77 | NPBWR1 (0.45) | PDE1APDE1BPDE1CNPBWR1PKM | |
| SCHEMBL2443709 | 0.76 | NPBWR1 (0.47) | PDE1APDE1BPDE1CNPBWR1PKM | |
| SCHEMBL29514413 | 0.76 | PDE1B (0.50) | PDE1APDE1BPDE1CNPBWR1PKM | |
| SCHEMBL29049927 | 0.76 | PDE1B (0.50) | PDE1APDE1BPDE1CNPBWR1PKM | |
| SCHEMBL16014472 | 0.75 | PDE1A (0.50) | PDE1APDE1BPDE1CNPBWR1PKM | |
| SCHEMBL18428510 | 0.74 | PDE1A (0.49) | PDE1APDE1BPDE1CNPBWR1PKM | |
| SCHEMBL27077682 | 0.74 | NPBWR1 (0.57) | PDE1APDE1BPDE1CNPBWR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018092047-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | JOINT STOCK COMPANY "BIOCAD" (RU) | 2018-05-24 | — | — | WO | disclosed |