Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPBWR1 | P48145 | 8/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 3/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25237607 | 0.87 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL3724625 | 0.86 | LMNA (0.51) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL15555752 | 0.85 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL4739369 | 0.85 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL20176618 | 0.85 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL16620668 | 0.83 | LMNA (0.53) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL1135057 | 0.81 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL31140630 | 0.81 | LMNA (0.49) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL25233586 | 0.81 | LMNA (0.49) | LMNAALDH1A1MAPTSMN1; SMN2HPGD | |
| SCHEMBL3717372 | 0.80 | LMNA (0.52) | LMNAALDH1A1MAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190352276-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | JOINT STOCK COMPANY "BIOCAD" (RU) | 2019-11-21 | — | — | US | disclosed |
| WO-2018092047-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | JOINT STOCK COMPANY "BIOCAD" (RU) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190352276-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, ABL1, CNKSR1 | LMNA 946/4885ALDH1A1 3977/4885MAPT 4703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.