Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GUSB | P08236 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15330739 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1GAAMPIGFER | |
| SCHEMBL2557542 | 0.80 | CYP1A1 (0.48) | KDM4EALDH1A1GAAHSD17B10GUSB | |
| SCHEMBL2554567 | 0.80 | MAPT (0.47) | KDM4EALDH1A1GAAMPIGFER | |
| SCHEMBL15329643 | 0.80 | ERN1 (0.47) | KDM4EALDH1A1GAALMNAPDGFRB | |
| SCHEMBL2551101 | 0.77 | PDGFRB (0.48) | ALDH1A1GAAGFERTDP1APP | |
| SCHEMBL2556342 | 0.74 | GSTP1 (0.46) | KDM4EALDH1A1MAPT | |
| SCHEMBL28527368 | 0.73 | KDM4E (0.48) | KDM4EALDH1A1GAAMPIAPOBEC3G | |
| SCHEMBL7476783 | 0.73 | MAPT (0.51) | KDM4EALDH1A1GAAMPIGFER | |
| SCHEMBL2560872 | 0.72 | SMPD3 (0.50) | ERN1AMY1A | |
| SCHEMBL21635975 | 0.72 | ACHE (0.39) | ALDH1A1GAALMNAAPPPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3535258-B1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-11-24 | — | — | EP | disclosed |
| WO-2018093569-A1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-24 | — | — | WO | disclosed |