Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | FPR3 | P25089 | 1/20 | 0.33 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | PTGIR | P43119 | 1/20 | 0.32 |
| ▸ | ASGR1 | P07306 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15017085 | 0.92 | CNR2 (0.38) | CNR2HTR2CSLC6A4HTR2AFPR3 | |
| SCHEMBL25568400 | 0.85 | NR1H2 (0.36) | CNR2HTR2CSLC6A4HTR2AFPR3 | |
| SCHEMBL6019334 | 0.85 | NR1H2 (0.43) | CNR2HTR2CSLC6A4HTR2AFPR3 | |
| SCHEMBL6019337 | 0.85 | NR1H2 (0.43) | CNR2HTR2CSLC6A4HTR2AFPR3 | |
| SCHEMBL25568402 | 0.85 | NR1H2 (0.36) | CNR2HTR2CSLC6A4HTR2AFPR3 | |
| SCHEMBL24438464 | 0.85 | ALOX5 (0.39) | CNR2HTR2CSLC6A4HTR2ALIMK2 | |
| SCHEMBL25568401 | 0.84 | CNR2 (0.34) | CNR2HTR2CSLC6A4HTR2AFPR3 | |
| SCHEMBL25568399 | 0.84 | CNR2 (0.34) | CNR2HTR2CSLC6A4HTR2AFPR3 | |
| SCHEMBL30157292 | 0.84 | PLG (0.38) | CNR2HTR2CSLC6A4HTR2AFPR3 | |
| SCHEMBL8911411 | 0.83 | HTR2C (0.42) | HTR2CSLC6A4HTR2AALOX5CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093569-A1 | SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-24 | — | — | WO | disclosed |