Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 8/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | LTK | P29376 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | PRKX | P51817 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | MST1R | Q04912 | 1/20 | 0.53 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30125124 | 0.85 | NOS1 (0.41) | BTKPLK4CHEK1AURKADAPK3 | |
| SCHEMBL2263127 | 0.80 | BTK (0.53) | BTKPLK4CHEK1AURKADAPK3 | |
| SCHEMBL16382710 | 0.80 | BTK (0.53) | BTKPLK4CHEK1AURKADAPK3 | |
| SCHEMBL31211411 | 0.80 | TSHR (0.47) | MAP2K1NOS1AXLMETAP2NPC1 | |
| SCHEMBL21458300 | 0.80 | TSHR (0.47) | MAP2K1NOS1AXLMETAP2NPC1 | |
| SCHEMBL21579384 | 0.76 | BTK (0.49) | BTKPLK4CHEK1AURKADAPK3 | |
| SCHEMBL30567547 | 0.76 | BTK (0.49) | BTKPLK4CHEK1AURKADAPK3 | |
| SCHEMBL29168382 | 0.76 | BTK (0.49) | BTKPLK4CHEK1AURKADAPK3 | |
| SCHEMBL14553409 | 0.76 | NOS1 (0.52) | PTK2NOS1AXLMETAP2 | |
| SCHEMBL31148280 | 0.76 | NOS1 (0.52) | PTK2NOS1AXLMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018092047-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | JOINT STOCK COMPANY "BIOCAD" (RU) | 2018-05-24 | — | — | WO | disclosed |