Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489653 | 0.81 | ANPEP (0.47) | ALDH1A1ANPEPENPEPFOLH1TP53 | |
| SCHEMBL20168324 | 0.80 | FOLH1 (0.61) | ALDH1A1L3MBTL1ANPEPENPEPFOLH1 | |
| SCHEMBL21577936 | 0.80 | ALDH1A1 (0.45) | ALDH1A1L3MBTL1ANPEPENPEPFOLH1 | |
| SCHEMBL20179140 | 0.80 | FOLH1 (0.61) | ALDH1A1L3MBTL1ANPEPENPEPFOLH1 | |
| SCHEMBL28260261 | 0.75 | RARB (0.54) | ALDH1A1TP53TSHRKMT2AMEN1 | |
| SCHEMBL3102413 | 0.73 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1TP53TSHRKMT2A | |
| SCHEMBL2160396 | 0.72 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1ANPEPENPEPFOLH1 | |
| SCHEMBL28452804 | 0.71 | EPHX1 (0.41) | ANPEPKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3484567 | 0.71 | NR1H4 (0.41) | ALDH1A1L3MBTL1ANPEPENPEPFOLH1 | |
| SCHEMBL25335074 | 0.70 | ANPEP (0.50) | ALDH1A1L3MBTL1ANPEPENPEPFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094334-A1 | PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-05-24 | — | — | WO | disclosed |