Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRB | P23467 | 9/20 | 0.60 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.44 |
| ▸ | PTPRA | P18433 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21570565 | 0.83 | PTPRB (0.55) | PTPRBLOXL2CYP4A11CYP4F2PTPN1 | |
| SCHEMBL18387729 | 0.81 | LOXL2 (0.53) | PTPRBLOXL2CYP4A11CYP4F2MAPT | |
| SCHEMBL2241573 | 0.78 | LOXL2 (0.56) | PTPRBLOXL2CYP4A11CYP4F2MAPT | |
| SCHEMBL9917356 | 0.75 | LOXL2 (0.61) | PTPRBLOXL2CYP4A11CYP4F2MAPT | |
| SCHEMBL131711 | 0.74 | LOXL2 (0.70) | LOXL2CYP4A11CYP4F2MAPTMEN1 | |
| SCHEMBL11172488 | 0.74 | PTPRB (0.58) | PTPRBPTPN1PTPN2PTPRAKMT2A | |
| SCHEMBL850747 | 0.74 | LOXL2 (0.59) | PTPRBLOXL2CYP4A11CYP4F2MAPT | |
| SCHEMBL23222275 | 0.74 | CYP4A11 (0.51) | PTPRBLOXL2CYP4A11CYP4F2MAPT | |
| SCHEMBL2490598 | 0.73 | PTPRB (0.46) | PTPRBLOXL2CYP4A11CYP4F2PTPN1 | |
| SCHEMBL1807631 | 0.73 | CYP4A11 (0.68) | LOXL2CYP4A11CYP4F2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094334-A1 | PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-05-24 | — | — | WO | disclosed |