Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20179269 | 0.87 | ELANE (0.36) | ELANEPPARGPOLBKMT2AMEN1 | |
| SCHEMBL20168293 | 0.86 | PPARG (0.43) | ELANEPPARGPPARAKMT2AMEN1 | |
| SCHEMBL21578021 | 0.82 | ELANE (0.44) | ELANEPPARGPPARAKMT2AMEN1 | |
| SCHEMBL20179174 | 0.75 | ELANE (0.45) | ELANEKMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL20179253 | 0.74 | PPARG (0.42) | ELANEPPARGPPARAKMT2AMEN1 | |
| SCHEMBL20168668 | 0.74 | PRSS1 (0.39) | ELANEPPARGPOLBKMT2AMEN1 | |
| SCHEMBL20179366 | 0.72 | PPARG (0.42) | PPARGPPARAKMT2AMEN1MAPT | |
| SCHEMBL20168734 | 0.72 | CA12 (0.45) | PPARGPPARAMAPTLMNAHPGD | |
| SCHEMBL20179146 | 0.72 | CA12 (0.45) | PPARGPPARAMAPTLMNAHPGD | |
| SCHEMBL20179228 | 0.71 | FOLH1 (0.39) | ELANEPPARGPPARAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094334-A1 | PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-05-24 | — | — | WO | disclosed |