Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168293 | 0.86 | PPARG (0.43) | PPARGKMT2AMEN1PPARALMNA | |
| SCHEMBL20168304 | 0.79 | SMN1; SMN2 (0.46) | PPARGKMT2AMEN1LMNAFOLH1 | |
| SCHEMBL20168303 | 0.77 | CYP4F2 (0.49) | PPARGPPARALMNAFOLH1ALDH1A1 | |
| SCHEMBL21578155 | 0.75 | FOLH1 (0.38) | PPARGPPARAFOLH1NPC1SMN1; SMN2 | |
| SCHEMBL20168733 | 0.75 | FOLH1 (0.38) | PPARGPPARAFOLH1NPC1SMN1; SMN2 | |
| SCHEMBL21578021 | 0.74 | ELANE (0.44) | PPARGKMT2AMEN1PPARALMNA | |
| SCHEMBL20168324 | 0.72 | FOLH1 (0.61) | FOLH1ALDH1A1 | |
| SCHEMBL20179140 | 0.72 | FOLH1 (0.61) | FOLH1ALDH1A1 | |
| SCHEMBL20179271 | 0.72 | ELANE (0.36) | PPARGKMT2AMEN1PPARALMNA | |
| SCHEMBL20179269 | 0.72 | ELANE (0.36) | PPARGKMT2AMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094334-A1 | PRODRUGS OF HYDROXAMATE-BASED GCPII INHIBITORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-05-24 | — | — | WO | disclosed |