SCHEMBL20179444

SCHEMBL20179444

CC(C)Sc1nc(O)c(C(=O)Nc2ccc(/C(=C/N)NN)cc2)c(=O)[nH]1

nearest known ligand 0.62

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 5/20 0.62
XDH P47989 16/20 0.59
TSHR P16473 1/20 0.39
HTT P42858 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20327740 0.84 XDH (0.46) SLC22A12XDH
SCHEMBL20179455 0.81 XDH (0.60) SLC22A12XDHHTTLMNAMAPT
SCHEMBL20915854 0.77 XDH (0.68) SLC22A12XDH
SCHEMBL20929095 0.74 XDH (0.70) SLC22A12XDH
SCHEMBL20929166 0.74 SLC22A12 (0.70) SLC22A12XDH
SCHEMBL20328079 0.74 XDH (0.61) SLC22A12XDH
SCHEMBL20929225 0.74 XDH (0.61) SLC22A12XDHMAPT
SCHEMBL20327801 0.72 XDH (0.63) SLC22A12XDH
SCHEMBL20915731 0.69 XDH (0.73) SLC22A12XDH
SCHEMBL20179427 0.67 XDH (0.61) SLC22A12XDHHTTLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018005192-A9 COMPOUNDS AND THEIR USE FOR REDUCING URIC ACID LEVELS ACQUIST LLC (US) 2018-05-24 WO disclosed