Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20179492 | 0.84 | SMN1; SMN2 (0.58) | POLBALDH1A1HPGDGAANPSR1 | |
| SCHEMBL1107021 | 0.79 | GAA (0.62) | POLBALDH1A1HPGDGAANPSR1 | |
| SCHEMBL10253878 | 0.77 | GAA (0.60) | POLBALDH1A1HPGDGAANPSR1 | |
| SCHEMBL17712437 | 0.76 | GAA (0.61) | POLBALDH1A1HPGDGAANPSR1 | |
| SCHEMBL15075357 | 0.76 | CYP2C19 (0.53) | POLBALDH1A1HPGDSMN1; SMN2RAB9A | |
| SCHEMBL20363266 | 0.76 | GAA (0.63) | POLBALDH1A1HPGDGAANPSR1 | |
| SCHEMBL24805790 | 0.75 | MAPT (0.57) | POLBALDH1A1HPGDGAANPSR1 | |
| SCHEMBL14047269 | 0.75 | CYP2C19 (0.49) | ALDH1A1NPSR1RAB9AMAPTKMT2A | |
| SCHEMBL28226208 | 0.74 | ALOX15 (0.62) | POLBALDH1A1HPGDGAANPSR1 | |
| SCHEMBL1709325 | 0.73 | HPGD (0.72) | POLBALDH1A1HPGDGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093695-A1 | FACTOR XIIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |