Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 4/20 | 0.38 |
| ▸ | CCND1 | P24385 | 4/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.38 |
| ▸ | CDK1 | P06493 | 3/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.38 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20164978 | 0.76 | GPR17 (0.43) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL18136510 | 0.75 | JAK2 (0.51) | — | |
| SCHEMBL20175450 | 0.73 | PIM3 (0.39) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL20164977 | 0.72 | NR4A2 (0.45) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL30484109 | 0.67 | AURKA (0.54) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL6883079 | 0.67 | AURKA (0.54) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL17204317 | 0.67 | BRD4 (0.43) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL22066486 | 0.67 | CDK4 (0.54) | CDK4CCND1CCNB2CDK1CCNB1 | |
| SCHEMBL14538194 | 0.65 | ALDH1A1 (0.46) | GAAGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL3610664 | 0.65 | JAK2 (0.52) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280418-B1 | AZACARBAZOLE BTK INHIBITORS | MERCK SHARP & DOHME (US) | 2020-05-06 | — | — | EP | disclosed |
| US-20180141962-A1 | AZACARBAZOLE BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180141962-A1 | AZACARBAZOLE BTK INHIBITORS | BTK, SYK, LYN | CDK4 190/4885CCND1 405/4885CCNB2 127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.