Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.46 |
| ▸ | NT5E | P21589 | 4/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21766000 | 0.95 | ADORA3 (0.49) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL20180027 | 0.92 | ADORA3 (0.47) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL21766006 | 0.92 | ADORA1 (0.46) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL21766007 | 0.87 | ADORA3 (0.60) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL22215119 | 0.86 | NT5E (0.52) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL21766031 | 0.86 | NT5E (0.46) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL21766029 | 0.85 | ADORA3 (0.49) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL20180037 | 0.85 | ADORA1 (0.47) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL21766013 | 0.84 | NT5E (0.47) | ADORA1ADORA3ADORA2ANT5EADORA2B | |
| SCHEMBL20180082 | 0.84 | ADORA3 (0.51) | ADORA1ADORA3ADORA2ANT5EADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094148-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | ARCUS BIOSCIENCES, INC. (US) | 2018-05-24 | — | — | WO | disclosed |