SCHEMBL20180146

SCHEMBL20180146

N=Cc1c(Nc2ccccc2)ccc2ccc(-c3cccc(Br)c3)cc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 4/20 0.38
ABCB1 P08183 3/20 0.38
CYP3A4 P08684 3/20 0.38
TSHR P16473 3/20 0.38
HPGD P15428 2/20 0.38
HSD17B10 Q99714 2/20 0.38
ALDH1A1 P00352 1/20 0.38
TP53 P04637 1/20 0.38
ALOX15 P16050 1/20 0.38
CDC25B P30305 1/20 0.38
ATM Q13315 1/20 0.38
EGFR P00533 3/20 0.38
ALK Q9UM73 2/20 0.36
ABCC1 P33527 2/20 0.36
MEN1 O00255 4/20 0.34
KMT2A Q03164 4/20 0.34
KDM4E B2RXH2 1/20 0.34
GLA P06280 1/20 0.34
GAA P10253 1/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20180275 0.82 EGFR (0.50) ABCG2ABCB1CYP3A4TSHRHPGD
SCHEMBL20180229 0.80 MEN1 (0.40) ABCG2ABCB1TSHRHPGDALDH1A1
SCHEMBL20180154 0.79 LIPG (0.41) CYP3A4TSHRHPGDHSD17B10ALDH1A1
SCHEMBL20180329 0.79 ABCB1 (0.37) ABCG2ABCB1EGFRABCC1SYK
SCHEMBL20180309 0.74 ABCG2 (0.41) ABCG2ABCB1HPGDALDH1A1EGFR
SCHEMBL20180184 0.73 ABCG2 (0.40) ABCG2ABCB1CYP3A4TSHRHPGD
SCHEMBL20180548 0.72 MEN1 (0.43) ABCG2ABCB1TSHRHPGDALDH1A1
SCHEMBL2454066 0.72 MEN1 (0.44) ABCG2ABCB1CYP3A4TSHRHPGD
SCHEMBL20180167 0.69 NPC1 (0.38) ALDH1A1EGFRALKMEN1KMT2A
SCHEMBL20615581 0.68 CDC25B (0.45) ABCG2ABCB1CYP3A4TSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018093107-A1 ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENT ELEMENT COMPRISING SAME 주식회사 두산 2018-05-24 WO disclosed