Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 11/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.44 |
| ▸ | NT5E | P21589 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21765919 | 0.88 | ADORA1 (0.47) | ADORA1ADORA2BADORA3ADORA2ANT5E | |
| SCHEMBL21766041 | 0.88 | NT5E (0.47) | ADORA1ADORA2BADORA3ADORA2ANT5E | |
| SCHEMBL20180035 | 0.84 | ADORA3 (0.44) | ADORA1ADORA2BADORA3ADORA2ANT5E | |
| SCHEMBL21766006 | 0.80 | ADORA1 (0.46) | ADORA1ADORA2BADORA3ADORA2ANT5E | |
| SCHEMBL22215144 | 0.80 | NT5E (0.53) | ADORA1ADORA2BADORA3ADORA2ANT5E | |
| SCHEMBL20180037 | 0.80 | ADORA1 (0.47) | ADORA1ADORA2BADORA3ADORA2ANT5E | |
| SCHEMBL20180039 | 0.80 | ADORA3 (0.47) | ADORA1ADORA2BADORA3ADORA2A | |
| SCHEMBL22215074 | 0.80 | NT5E (0.54) | ADORA1ADORA2BADORA3ADORA2ANT5E | |
| SCHEMBL21766031 | 0.80 | NT5E (0.46) | ADORA1ADORA2BADORA3ADORA2ANT5E | |
| SCHEMBL20180283 | 0.76 | ADORA1 (0.60) | ADORA1ADORA2BADORA3ADORA2ANT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094148-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | ARCUS BIOSCIENCES, INC. (US) | 2018-05-24 | — | — | WO | disclosed |