Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 10/20 | 0.52 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.52 |
| ▸ | NT5E | P21589 | 7/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20167811 | 0.89 | ADORA3 (0.63) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL21765999 | 0.85 | ADORA3 (0.59) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL29493240 | 0.85 | ADORA1 (0.64) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL20180038 | 0.85 | ADORA1 (0.64) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL20168221 | 0.85 | ADORA3 (0.61) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL20180112 | 0.85 | NT5E (0.60) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL22215085 | 0.83 | NT5E (0.57) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL21766034 | 0.83 | ADORA3 (0.64) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL20180017 | 0.83 | ADORA1 (0.53) | ADORA3ADORA1ADORA2ANT5EADORA2B | |
| SCHEMBL20180127 | 0.83 | NT5E (0.60) | ADORA3ADORA1ADORA2ANT5EADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094148-A1 | INHIBITORS OF CD73-MEDIATED IMMUNOSUPPRESSION | ARCUS BIOSCIENCES, INC. (US) | 2018-05-24 | — | — | WO | disclosed |