Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | RAD52 | P43351 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934165 | 0.83 | MAPT (0.49) | KDM4EMAPTRAD52POLBALDH1A1 | |
| SCHEMBL14922275 | 0.82 | POLB (0.71) | KDM4EMAPTRAD52POLBDRD2 | |
| SCHEMBL24518336 | 0.81 | KDM4E (0.54) | KDM4EMAPTRAD52POLBALDH1A1 | |
| SCHEMBL12082638 | 0.81 | MAPT (0.64) | KDM4EMAPTRAD52POLBDRD2 | |
| SCHEMBL31744855 | 0.79 | MAPT (0.62) | KDM4EMAPTRAD52POLBDRD2 | |
| SCHEMBL19625789 | 0.79 | ALDH1A1 (0.67) | KDM4EMAPTRAD52POLBDRD2 | |
| SCHEMBL156279 | 0.79 | MAPT (0.96) | KDM4EMAPTRAD52POLBDRD2 | |
| SCHEMBL29566344 | 0.79 | MAPT (0.62) | KDM4EMAPTRAD52POLBDRD2 | |
| SCHEMBL24309781 | 0.79 | MAPT (0.62) | KDM4EMAPTRAD52POLBDRD2 | |
| SCHEMBL29507813 | 0.79 | MAPT (0.96) | KDM4EMAPTRAD52POLBDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022124748-A1 | PYRAZOLOPYRIMIDINE SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PROPHYLAXIS OR TREATMENT OF CANCER-RELATED DISEASE COMPRISING SAME AS ACTIVE INGREDIENT | 한국화학연구원 | 2022-06-16 | — | — | WO | disclosed |
| WO-2018090939-A1 | 8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND | 上海瑛派药业有限公司 | 2018-05-24 | — | — | WO | disclosed |