Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 3/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 8/20 | 0.43 |
| ▸ | BRD4 | O60885 | 7/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27441812 | 0.76 | TNKS2 (0.33) | CREBBPBRD4EP300NOS2TSHR | |
| SCHEMBL16745966 | 0.74 | CREBBP (0.41) | NISCHCREBBPBRD4EP300RAB9A | |
| SCHEMBL6419356 | 0.69 | CREBBP (0.59) | CREBBPBRD4EP300RAB9ATSHR | |
| SCHEMBL29660000 | 0.69 | CREBBP (0.59) | CREBBPBRD4EP300RAB9ATSHR | |
| SCHEMBL16746009 | 0.66 | BRD4 (0.59) | CREBBPBRD4EP300RAB9ANOS2 | |
| SCHEMBL29572486 | 0.66 | CREBBP (0.55) | CREBBPBRD4EP300RAB9ATSHR | |
| SCHEMBL12837999 | 0.66 | CREBBP (0.55) | CREBBPBRD4EP300RAB9ATSHR | |
| SCHEMBL1736809 | 0.66 | CREBBP (0.55) | CREBBPBRD4EP300RAB9ATSHR | |
| SCHEMBL1868013 | 0.66 | CREBBP (0.55) | CREBBPBRD4EP300RAB9ATSHR | |
| SCHEMBL33268 | 0.66 | CREBBP (0.55) | CREBBPBRD4EP300RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093797-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ABERRANT ANGIOGENESIS | THE SCHEPENS EYE RESEARCH INSTITUTE, INC. (US) | 2018-05-24 | — | — | WO | disclosed |