Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | RAD52 | P43351 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20180601 | 0.82 | ALDH1A1 (0.41) | ALDH1A1HTTMAPTKDM4ERAD52 | |
| SCHEMBL29533302 | 0.82 | MAPT (0.56) | ALDH1A1HTTMAPTKDM4ERAD52 | |
| SCHEMBL23262628 | 0.82 | MAPT (0.56) | ALDH1A1HTTMAPTKDM4ERAD52 | |
| SCHEMBL11202420 | 0.82 | ALDH1A1 (0.69) | ALDH1A1HTTMAPTKDM4ERAD52 | |
| SCHEMBL10126811 | 0.82 | MAPT (0.56) | ALDH1A1HTTMAPTKDM4ERAD52 | |
| SCHEMBL1046324 | 0.81 | ALDH1A1 (0.49) | ALDH1A1HTTMAPTKDM4ERAD52 | |
| SCHEMBL29532627 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HTTMAPTKDM4ERAD52 | |
| SCHEMBL23246126 | 0.81 | ALDH1A1 (0.40) | ALDH1A1HTTMAPTKDM4ERAD52 | |
| SCHEMBL14320572 | 0.81 | ALDH1A1 (0.62) | ALDH1A1HTTMAPTKDM4ERAD52 | |
| SCHEMBL1046325 | 0.81 | ALDH1A1 (0.49) | ALDH1A1HTTMAPTKDM4ERAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019011228-A1 | IMIDAZO[1,2-B]PYRIMIDO[4,5-D]PYRIDAZIN-5(6H)-ONE COMPOUND AND USE THEREOF | 上海瑛派药业有限公司 | 2019-01-17 | — | — | WO | disclosed |
| WO-2018090939-A1 | 8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND | 上海瑛派药业有限公司 | 2018-05-24 | — | — | WO | disclosed |