Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | IKBKB | O14920 | 3/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 1.00 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 1.00 |
| ▸ | BCL2 | P10415 | 1/20 | 1.00 |
| ▸ | TXN | P10599 | 1/20 | 1.00 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 1.00 |
| ▸ | MCL1 | Q07820 | 1/20 | 1.00 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 1.00 |
| ▸ | SPTSSB | Q8NFR3 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gambogic Acid SCHEMBL12045553 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL12025441 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL7946944 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL12751296 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL134152 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL24089082 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL13685811 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL13685812 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL12859660 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 | |
| Gambogic Acid SCHEMBL12026374 | 1.00 | TP53 (1.00) | TP53MAPTMAPK1HSD17B10PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018092725-A1 | p53 DEGRADATION INDUCING MOLECULE AND PHARMACEUTICAL COMPOSITION | 学校法人東京理科大学 | 2018-05-24 | — | — | WO | disclosed |