Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 8/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.60 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20163073 | 0.92 | HDAC2 (0.72) | HDAC2HDAC3HDAC1KCNH2 | |
| SCHEMBL20163098 | 0.89 | HDAC3 (0.57) | HDAC2HDAC3WNT3AHDAC1GPR119 | |
| SCHEMBL21538765 | 0.88 | TBK1 (0.60) | HDAC2HDAC3TBK1WNT3AHDAC1 | |
| SCHEMBL20163160 | 0.88 | HDAC2 (0.54) | HDAC2HDAC3TBK1WNT3AHDAC1 | |
| SCHEMBL20181707 | 0.88 | HDAC2 (0.46) | HDAC2HDAC3TBK1WNT3AHDAC1 | |
| SCHEMBL20163078 | 0.87 | HDAC2 (0.55) | HDAC2HDAC3TBK1WNT3AHDAC1 | |
| SCHEMBL20181716 | 0.87 | HDAC3 (0.61) | HDAC2HDAC3TBK1WNT3AHDAC1 | |
| SCHEMBL20181825 | 0.86 | HDAC3 (0.56) | HDAC2HDAC3TBK1WNT3AHDAC1 | |
| SCHEMBL20163138 | 0.86 | HDAC2 (0.56) | HDAC2HDAC3TBK1WNT3AHDAC1 | |
| SCHEMBL23960982 | 0.85 | HDAC3 (0.48) | HDAC2HDAC3WNT3AGPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542242-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | REGENACY PHARMACEUTICALS, LLC (US) | 2023-01-03 | — | — | US | disclosed |
| US-20200377465-A1 | SUBSTITUTED PIPERAZINES AS SELECTIVE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS, LLC | 2020-12-03 | — | — | US | disclosed |
| US-10774056-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | REGENACY PHARMACEUTICALS, INC. (US) | 2020-09-15 | — | — | US | disclosed |
| US-20190330169-A1 | SELECTIVE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS, LLC | 2019-10-31 | — | — | US | disclosed |
| US-10385031-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | REGENACY PHARMACEUTICALS, LLC (US) | 2019-08-20 | — | — | US | disclosed |
| US-20180141923-A1 | SELECTIVE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS, LLC | 2018-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10385031-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | HDAC1, HDAC2, HDAC11 | HDAC2 2/4885HDAC3 7/4885TBK1 2876/4885 |
| US-11542242-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | HDAC1, HDAC2, HDAC11 | HDAC2 2/4885HDAC3 8/4885TBK1 3275/4885 |
| US-20180141923-A1 | SELECTIVE HDAC1,2 INHIBITORS | HDAC1, HDAC2, HDAC11 | HDAC2 2/4885HDAC3 6/4885TBK1 2693/4885 |
| US-10774056-B2 | Substituted piperazines as selective HDAC1,2 inhibitors | HDAC1, HDAC2, HDAC11 | HDAC2 2/4885HDAC3 7/4885TBK1 2844/4885 |
| US-20200377465-A1 | SUBSTITUTED PIPERAZINES AS SELECTIVE HDAC1,2 INHIBITORS | HDAC1, HDAC2, HDAC11 | HDAC2 2/4885HDAC3 7/4885TBK1 2948/4885 |
| US-20190330169-A1 | SELECTIVE HDAC1,2 INHIBITORS | HDAC1, HDAC2, HDAC11 | HDAC2 2/4885HDAC3 6/4885TBK1 2693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.