Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30892153 | 0.89 | RET (0.33) | RETKDRMAPK13MAPK12MAPK11 | |
| SCHEMBL20162979 | 0.89 | RET (0.33) | RETKDRMAPK13MAPK12MAPK11 | |
| SCHEMBL20182216 | 0.88 | KDR (0.40) | RETKDRSRCPIK3CD | |
| SCHEMBL20173304 | 0.79 | KDR (0.40) | RETKDRSRCPIK3CD | |
| SCHEMBL20162795 | 0.79 | KDR (0.42) | RETKDRSRCPIK3CD | |
| SCHEMBL30036859 | 0.79 | KDR (0.42) | RETKDRSRCPIK3CD | |
| SCHEMBL20162933 | 0.78 | PIK3CD (0.43) | RETKDRSRCPIK3CD | |
| SCHEMBL30037531 | 0.78 | PIK3CD (0.43) | RETKDRSRCPIK3CD | |
| SCHEMBL20181869 | 0.77 | MEN1 (0.36) | MAPK13MAPK12MAPK11MAPK14MGAM | |
| SCHEMBL20175297 | 0.76 | KDR (0.42) | RETKDRSRCPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |