Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.32 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162739 | 0.88 | CXCR2 (0.35) | MEN1KMT2ANR2F2ACP1MAPK13 | |
| SCHEMBL30037624 | 0.88 | CXCR2 (0.35) | MEN1KMT2ANR2F2ACP1MAPK13 | |
| SCHEMBL30038073 | 0.78 | SRC (0.47) | SRC | |
| SCHEMBL20162580 | 0.78 | SRC (0.47) | SRC | |
| SCHEMBL20162902 | 0.78 | DYRK3 (0.41) | SRC | |
| SCHEMBL30037066 | 0.78 | DYRK3 (0.41) | SRC | |
| SCHEMBL20181875 | 0.77 | RET (0.34) | MEN1KMT2ANR2F2MAPK13MAPK12 | |
| SCHEMBL20182174 | 0.73 | DRD2 (0.40) | MEN1KMT2ANR2F2GRIN2BADK | |
| SCHEMBL20182201 | 0.71 | NOTUM (0.48) | GRIN2BKCNH2 | |
| SCHEMBL20162748 | 0.70 | SRC (0.43) | SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |