Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.42 |
| ▸ | KDR | P35968 | 9/20 | 0.41 |
| ▸ | SRC | P12931 | 7/20 | 0.41 |
| ▸ | TEK | Q02763 | 7/20 | 0.41 |
| ▸ | LCK | P06239 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 5/20 | 0.40 |
| ▸ | ABL2 | P42684 | 5/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182296 | 0.87 | CFTR (0.41) | EGFRKDRSRCTEKLCK | |
| SCHEMBL20182224 | 0.85 | EGFR (0.39) | EGFRKDRSRCTEKLCK | |
| SCHEMBL20182204 | 0.83 | KDR (0.37) | EGFRKDRSRCTEKLCK | |
| SCHEMBL20182275 | 0.81 | EGFR (0.36) | EGFRKDRSRCTEKLCK | |
| SCHEMBL20182255 | 0.78 | SRC (0.39) | EGFRKDRSRCTEKLCK | |
| SCHEMBL20182191 | 0.78 | ALK (0.34) | EGFRKDRSRCTEKABL1 | |
| SCHEMBL20182197 | 0.78 | CFTR (0.43) | EGFRKDRSRCTEKLCK | |
| SCHEMBL20181912 | 0.77 | SRC (0.41) | EGFRKDRSRCTEKLCK | |
| SCHEMBL20182225 | 0.77 | CFTR (0.39) | EGFRKDRSRCTEKABL1 | |
| SCHEMBL20182292 | 0.77 | NEK7 (0.37) | EGFRKDRSRCTEKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |