Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 10/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 7/20 | 0.41 |
| ▸ | EGFR | P00533 | 7/20 | 0.41 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | CFTR | P13569 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20173318 | 0.90 | TEK (0.41) | SRCRIPK2ABL1EGFRKDR | |
| SCHEMBL20173321 | 0.88 | SRC (0.52) | SRCRIPK2ABL1EGFRKDR | |
| SCHEMBL20162676 | 0.87 | CFTR (0.41) | SRCRIPK2ABL1EGFRKDR | |
| SCHEMBL30037245 | 0.87 | CFTR (0.41) | SRCRIPK2ABL1EGFRKDR | |
| SCHEMBL20162596 | 0.85 | PTGS2 (0.45) | SRCCFTRCA2CA5ACA9 | |
| SCHEMBL30037644 | 0.85 | PTGS2 (0.45) | SRCCFTRCA2CA5ACA9 | |
| SCHEMBL20173314 | 0.85 | CFTR (0.40) | SRCCFTRCA2CA5ACA9 | |
| SCHEMBL20162830 | 0.84 | SRC (0.41) | SRCKDRLCKTEKCFTR | |
| SCHEMBL20175298 | 0.83 | SRC (0.42) | SRCRIPK2ABL1EGFRKDR | |
| SCHEMBL23481428 | 0.82 | EIF2AK3 (0.41) | SRCRIPK2ABL1LCKHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |