Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.47 |
| ▸ | TEK | Q02763 | 8/20 | 0.47 |
| ▸ | LCK | P06239 | 7/20 | 0.47 |
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | BTK | Q06187 | 3/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ABL2 | P42684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182279 | 0.80 | FYN (0.39) | SRCTEKLCKKDRBTK | |
| SCHEMBL20182223 | 0.79 | RPS6KA3 (0.40) | SRCTEKLCKKDRBTK | |
| SCHEMBL3662271 | 0.74 | SRC (0.64) | SRCTEKLCKKDRFLT3 | |
| SCHEMBL13020061 | 0.73 | SRC (0.57) | SRCTEKLCKKDRBTK | |
| SCHEMBL13020062 | 0.72 | SRC (0.60) | SRCTEKLCKKDRBTK | |
| SCHEMBL13020097 | 0.72 | SRC (0.57) | SRCTEKLCKKDRFLT3 | |
| SCHEMBL13020112 | 0.72 | SRC (0.58) | SRCTEKLCKKDRFLT3 | |
| SCHEMBL13020101 | 0.72 | SRC (0.67) | SRCTEKLCKKDRFLT3 | |
| SCHEMBL13020349 | 0.71 | SRC (0.69) | SRCTEKLCKKDRFLT3 | |
| SCHEMBL20162680 | 0.71 | SRC (0.51) | SRCTEKLCKKDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |