Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 4/20 | 0.34 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 3/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | ABL2 | P42684 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 6/20 | 0.32 |
| ▸ | SRC | P12931 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | TEK | Q02763 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | SIK1 | P57059 | 1/20 | 0.30 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182271 | 0.91 | CFTR (0.35) | AXLEIF2AK3EGFRABL1ABL2 | |
| SCHEMBL20182275 | 0.91 | EGFR (0.36) | AXLEIF2AK3EGFRABL1ABL2 | |
| SCHEMBL20182235 | 0.91 | EIF2AK3 (0.34) | AXLEIF2AK3EGFRABL1ABL2 | |
| SCHEMBL20182194 | 0.90 | EIF2AK3 (0.36) | EIF2AK3EGFRABL1ABL2RET | |
| SCHEMBL20182289 | 0.89 | NTRK1 (0.36) | AXLEIF2AK3EGFRABL1ABL2 | |
| SCHEMBL20182191 | 0.85 | ALK (0.34) | AXLEIF2AK3EGFRABL1ABL2 | |
| SCHEMBL20182225 | 0.83 | CFTR (0.39) | AXLEGFRABL1ABL2RET | |
| SCHEMBL20182292 | 0.83 | NEK7 (0.37) | EIF2AK3EGFRABL1ABL2SRC | |
| SCHEMBL20182265 | 0.81 | NTRK1 (0.36) | AXLEIF2AK3EGFRABL1ABL2 | |
| SCHEMBL20182224 | 0.81 | EGFR (0.39) | EGFRABL1ABL2RETSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |