Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | NEK7 | Q8TDX7 | 2/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 4/20 | 0.33 |
| ▸ | RET | P07949 | 3/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | SRC | P12931 | 3/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | SIK1 | P57059 | 1/20 | 0.32 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.32 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20181904 | 0.89 | PDPK1 (0.36) | EGFRERBB2ERBB3TEKERBB4 | |
| SCHEMBL20182248 | 0.87 | LRRK2 (0.34) | EGFRERBB2ERBB3TEKERBB4 | |
| SCHEMBL20181907 | 0.86 | EGFR (0.35) | EGFRERBB2ERBB3TEKERBB4 | |
| SCHEMBL20182195 | 0.82 | NTRK1 (0.33) | EGFRERBB2ERBB3TEKERBB4 | |
| SCHEMBL20181912 | 0.82 | SRC (0.41) | EGFRTEKSRCPIK3CDEIF2AK3 | |
| SCHEMBL20182295 | 0.82 | MTOR (0.33) | EGFRERBB2ERBB3TEKERBB4 | |
| SCHEMBL20182255 | 0.82 | SRC (0.39) | EGFRTEKNEK7SRCPIK3CD | |
| SCHEMBL20182197 | 0.81 | CFTR (0.43) | EGFRTEKSRCPIK3CDEIF2AK3 | |
| SCHEMBL20182198 | 0.80 | SRC (0.34) | EGFRTEKNEK7RETSRC | |
| SCHEMBL20182227 | 0.80 | EGFR (0.36) | EGFRTEKNEK7RETSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |