Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.32 |
| ▸ | TEK | Q02763 | 4/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | HCK | P08631 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
| ▸ | NEK7 | Q8TDX7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182263 | 0.86 | CFTR (0.40) | LRRK2 | |
| SCHEMBL20182204 | 0.85 | KDR (0.37) | KDRTEKLCKPIK3CDABL1 | |
| SCHEMBL20182269 | 0.81 | CFTR (0.38) | LRRK2FLT3 | |
| SCHEMBL20181896 | 0.80 | CFTR (0.42) | FLT3NEK7 | |
| SCHEMBL20182220 | 0.77 | CFTR (0.39) | KDRTEKLCKLRRK2NEK7 | |
| SCHEMBL20182354 | 0.77 | CFTR (0.41) | KDRTEKLRRK2 | |
| SCHEMBL20182255 | 0.74 | SRC (0.39) | KDRTEKLCKPIK3CDABL1 | |
| SCHEMBL30036351 | 0.74 | CFTR (0.52) | — | |
| SCHEMBL20163115 | 0.74 | CFTR (0.52) | — | |
| SCHEMBL20182197 | 0.72 | CFTR (0.43) | KDRTEKLCKPIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |