Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 13/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | NEK7 | Q8TDX7 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182263 | 0.93 | CFTR (0.40) | CFTRRIPK1 | |
| SCHEMBL20182356 | 0.91 | CFTR (0.39) | CFTRNTRK1NTRK3NTRK2RIPK1 | |
| SCHEMBL20182269 | 0.90 | CFTR (0.38) | CFTRFLT3RIPK1 | |
| SCHEMBL20182268 | 0.90 | CFTR (0.42) | CFTRFLT3NTRK1NTRK3NTRK2 | |
| SCHEMBL20182294 | 0.85 | CFTR (0.40) | CFTRFLT3NTRK1NTRK3NTRK2 | |
| SCHEMBL20182220 | 0.84 | CFTR (0.39) | CFTRNEK7 | |
| SCHEMBL20182354 | 0.83 | CFTR (0.41) | CFTRRIPK1 | |
| SCHEMBL20182278 | 0.83 | CFTR (0.37) | CFTRNTRK1NTRK3NTRK2RIPK1 | |
| SCHEMBL20182355 | 0.81 | CFTR (0.38) | CFTRRIPK1 | |
| SCHEMBL20182353 | 0.80 | KDR (0.32) | FLT3NEK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |