Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 18/20 | 0.62 |
| ▸ | SCN1A | P35498 | 12/20 | 0.62 |
| ▸ | SCN8A | Q9UQD0 | 12/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16177329 | 0.88 | SCN5A (0.59) | SCN5ASCN1ASCN8AUSP2MAPT | |
| SCHEMBL20096109 | 0.88 | SCN5A (0.62) | SCN5ASCN1ASCN8ASCN1B | |
| SCHEMBL20095581 | 0.88 | SCN5A (0.59) | SCN5ASCN1ASCN8AUSP2MAPT | |
| SCHEMBL21964962 | 0.86 | SCN5A (0.66) | SCN5ASCN1ASCN8ASCN1BCYP3A4 | |
| SCHEMBL19011638 | 0.86 | SCN5A (0.66) | SCN5ASCN1ASCN8ASCN1BCYP3A4 | |
| SCHEMBL30479362 | 0.83 | USP2 (0.78) | SCN5ASCN1ASCN8AUSP2MAPT | |
| SCHEMBL15010806 | 0.82 | SCN5A (0.59) | SCN5ASCN1ASCN8AUSP2MAPT | |
| SCHEMBL713278 | 0.81 | HSD11B1 (0.57) | SCN5ASCN1ASCN8AUSP2MAPT | |
| SCHEMBL19401003 | 0.80 | SCN9A (0.69) | SCN5ACYP3A4SCN9A | |
| SCHEMBL20256510 | 0.79 | SCN5A (0.66) | SCN5ASCN1ASCN8ACYP3A4SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018093694-A1 | DIAMINO-ALKYLAMINO-LINKED ARYLSULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS | MERCK SHARP & DOHME CORP. (US) | 2018-05-24 | — | — | WO | disclosed |