SCHEMBL2018328

SCHEMBL2018328

N[C@@H](C(=O)C(=O)CP(=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@H](O)[C@@H]1O)OP(=O)(O)O)[C@@H](O)[C@@H](O)[C@H](O)CO

nearest known ligand 0.57

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
P2RY2 P41231 12/20 0.57
P2RY6 Q15077 10/20 0.57
P2RY4 P51582 6/20 0.57
P2RY14 Q15391 6/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL692573 0.90 P2RY14 (0.53) P2RY2P2RY6P2RY4P2RY14
Uridine SCHEMBL2018331 0.88 P2RY2 (0.60) P2RY2P2RY6P2RY4P2RY14
Uridine_Diphosphate SCHEMBL16193777 0.87 P2RY6 (0.65) P2RY2P2RY6P2RY4P2RY14
Uridine SCHEMBL1835845 0.83 SLC28A1 (0.58) P2RY2P2RY6P2RY4P2RY14
Uridine SCHEMBL3684420 0.83 SLC28A1 (0.58) P2RY2P2RY6P2RY4P2RY14
SCHEMBL454079 0.81 P2RY6 (0.61) P2RY2P2RY6P2RY4P2RY14
SCHEMBL21295127 0.81 P2RY6 (0.61) P2RY2P2RY6P2RY4P2RY14
Uridine_Diphosphate SCHEMBL25247163 0.81 P2RY6 (0.70) P2RY2P2RY6P2RY4P2RY14
Uridine_Diphosphate SCHEMBL15641268 0.81 P2RY6 (0.67) P2RY2P2RY6P2RY4P2RY14
Uridine_Diphosphate SCHEMBL3054330 0.81 P2RY6 (0.67) P2RY2P2RY6P2RY4P2RY14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8435763-B2 from cultures of microorganisms in the presence of enzymes; used for immunotherapy, preventing bacterial or viral infections and treating cardiovascular disorders KYOWA HAKKO BIO CO., LTD. (JP) 2013-05-07 US claimed
US-20050019874-A1 Processes for producing sugar nucleotides and complex carbohydrates KYOWA HAKKO KOGYO CO., LTD. (JP) 2005-01-27 US claimed
WO-2011078987-A1 RECOMBINANT PROKARYOTES AND USE THEREOF FOR PRODUCTION OF O-GLYCOSYLATED PROTEINS TRUSTEES OF DARTMOUTH COLLEGE (US) 2011-06-30 WO disclosed