Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 17/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184208 | 0.90 | AAK1 (0.49) | AAK1HDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL16637192 | 0.77 | AAK1 (0.83) | AAK1 | |
| SCHEMBL16636140 | 0.75 | AAK1 (1.00) | AAK1 | |
| SCHEMBL16646759 | 0.71 | AAK1 (0.53) | AAK1HDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL20184203 | 0.67 | AAK1 (0.60) | AAK1HDAC6 | |
| SCHEMBL16636431 | 0.67 | AAK1 (1.00) | AAK1 | |
| SCHEMBL16636151 | 0.67 | AAK1 (1.00) | AAK1 | |
| SCHEMBL16635924 | 0.66 | AAK1 (1.00) | AAK1 | |
| SCHEMBL16646867 | 0.66 | AAK1 (1.00) | AAK1 | |
| SCHEMBL19261677 | 0.64 | AAK1 (0.85) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |