Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 16/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184207 | 0.90 | AAK1 (0.59) | AAK1HDAC4HDAC7HDAC9HDAC5 | |
| SCHEMBL20184203 | 0.70 | AAK1 (0.60) | AAK1HDAC6 | |
| SCHEMBL11362818 | 0.66 | HDAC6 (0.50) | HDAC4HDAC6 | |
| SCHEMBL16637192 | 0.66 | AAK1 (0.83) | AAK1 | |
| SCHEMBL16636431 | 0.66 | AAK1 (1.00) | AAK1 | |
| SCHEMBL16636151 | 0.66 | AAK1 (1.00) | AAK1 | |
| SCHEMBL16635800 | 0.66 | L3MBTL1 (0.47) | AAK1HDAC6CNR1CNR2 | |
| SCHEMBL4750636 | 0.66 | HSD17B2 (0.49) | HDAC6CNR1CNR2 | |
| SCHEMBL11370838 | 0.65 | PTPN1 (0.58) | — | |
| SCHEMBL11361867 | 0.65 | MAPK1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |