Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.60 |
| ▸ | JAK2 | O60674 | 13/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.49 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184496 | 0.86 | JAK3 (0.56) | JAK3JAK2JAK1 | |
| SCHEMBL20184546 | 0.86 | JAK3 (0.60) | JAK3JAK2JAK1 | |
| SCHEMBL16245362 | 0.86 | JAK3 (0.79) | JAK3JAK2JAK1 | |
| SCHEMBL20184591 | 0.85 | JAK2 (0.73) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184347 | 0.85 | JAK3 (0.62) | JAK3JAK2JAK1 | |
| SCHEMBL20184690 | 0.84 | JAK3 (0.79) | JAK3JAK2JAK1 | |
| SCHEMBL20184721 | 0.84 | JAK3 (0.73) | JAK3JAK2JAK1 | |
| SCHEMBL20184691 | 0.84 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL20184345 | 0.83 | JAK3 (0.62) | JAK3JAK2ROCK2LIMK1JAK1 | |
| SCHEMBL20184692 | 0.83 | JAK3 (0.70) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |