Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15032822 | 0.87 | JAK3 (0.67) | JAK3JAK2JAK1 | |
| SCHEMBL20184413 | 0.86 | JAK3 (0.56) | JAK3JAK2JAK1 | |
| SCHEMBL20184583 | 0.84 | MAPT (0.48) | JAK3ALDH1A1MAPTJAK2JAK1 | |
| SCHEMBL20184447 | 0.78 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL20184666 | 0.77 | JAK3 (0.53) | JAK3JAK2JAK1 | |
| SCHEMBL20184416 | 0.77 | JAK3 (0.53) | JAK3JAK2JAK1 | |
| SCHEMBL20184577 | 0.77 | JAK3 (0.56) | JAK3JAK2JAK1 | |
| SCHEMBL20184457 | 0.77 | JAK3 (0.77) | JAK3JAK2JAK1 | |
| SCHEMBL15010792 | 0.77 | JAK3 (0.62) | JAK3JAK2JAK1 | |
| SCHEMBL20184561 | 0.77 | JAK3 (0.77) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |