Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 9/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184640 | 0.88 | JAK3 (0.45) | JAK3JAK2JAK1 | |
| SCHEMBL20184462 | 0.84 | JAK3 (0.50) | MAPTALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL20184481 | 0.82 | CYP3A4 (0.48) | MAPTALDH1A1NPC1RAB9AJAK3 | |
| SCHEMBL20184397 | 0.80 | JAK3 (0.62) | JAK3JAK2JAK1 | |
| SCHEMBL20184578 | 0.80 | JAK3 (0.41) | JAK3KDM4EJAK2JAK1 | |
| SCHEMBL20184687 | 0.80 | JAK3 (0.41) | JAK3JAK2JAK1 | |
| SCHEMBL16245208 | 0.80 | JAK3 (0.61) | JAK3JAK2JAK1 | |
| SCHEMBL20184545 | 0.80 | JAK3 (0.45) | JAK3JAK2JAK1 | |
| SCHEMBL20184567 | 0.79 | JAK3 (0.58) | JAK3JAK2JAK1 | |
| SCHEMBL16245166 | 0.79 | JAK3 (0.58) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |