Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.54 |
| ▸ | JAK2 | O60674 | 15/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184459 | 0.85 | JAK2 (0.71) | JAK3JAK2ROCK2LIMK1LIMK2 | |
| SCHEMBL20184499 | 0.85 | JAK2 (0.54) | JAK3JAK2ROCK2LIMK1ROCK1 | |
| SCHEMBL15032560 | 0.84 | JAK3 (0.77) | JAK3JAK2 | |
| SCHEMBL20184476 | 0.84 | JAK3 (0.60) | JAK3JAK2 | |
| SCHEMBL20184701 | 0.83 | JAK2 (0.61) | JAK3JAK2ROCK2LIMK1ROCK1 | |
| SCHEMBL20184346 | 0.82 | JAK2 (0.67) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184553 | 0.82 | JAK2 (0.67) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184454 | 0.82 | JAK3 (0.70) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184432 | 0.82 | JAK3 (0.68) | JAK3JAK2ROCK2LIMK1 | |
| SCHEMBL20184363 | 0.81 | JAK3 (0.55) | JAK3JAK2ROCK2LIMK1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |