Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.54 |
| ▸ | JAK3 | P52333 | 13/20 | 0.54 |
| ▸ | PIM1 | P11309 | 3/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.49 |
| ▸ | CDC7 | O00311 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184553 | 0.86 | JAK2 (0.67) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL20184454 | 0.86 | JAK3 (0.70) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL20184346 | 0.86 | JAK2 (0.67) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL20184432 | 0.86 | JAK3 (0.68) | JAK2JAK3ROCK2LIMK1 | |
| SCHEMBL20184476 | 0.86 | JAK3 (0.60) | JAK2JAK3 | |
| SCHEMBL20184353 | 0.86 | JAK3 (0.55) | JAK2JAK3PIM1PIM3ROCK2 | |
| SCHEMBL20184701 | 0.85 | JAK2 (0.61) | JAK2JAK3ROCK2ROCK1LIMK1 | |
| SCHEMBL20184686 | 0.85 | JAK3 (0.55) | JAK2JAK3ROCK2ROCK1LIMK1 | |
| SCHEMBL20184363 | 0.85 | JAK3 (0.55) | JAK2JAK3ROCK2ROCK1LIMK1 | |
| SCHEMBL20184511 | 0.85 | JAK3 (0.54) | JAK2JAK3ROCK2ROCK1LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |