Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.58 |
| ▸ | JAK2 | O60674 | 2/20 | 0.58 |
| ▸ | BTK | Q06187 | 6/20 | 0.47 |
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184680 | 0.90 | JAK3 (0.49) | JAK3JAK2JAK1 | |
| SCHEMBL20184521 | 0.90 | JAK3 (0.59) | JAK3JAK2JAK1AURKA | |
| SCHEMBL20184508 | 0.90 | JAK3 (0.59) | JAK3JAK2JAK1AURKA | |
| SCHEMBL20184539 | 0.89 | JAK3 (0.51) | JAK3JAK2BTKITKJAK1 | |
| SCHEMBL20184704 | 0.89 | JAK3 (0.59) | JAK3JAK2JAK1AURKA | |
| SCHEMBL20184557 | 0.88 | JAK3 (0.47) | JAK3JAK2JAK1AURKA | |
| SCHEMBL20184481 | 0.87 | CYP3A4 (0.48) | JAK3JAK2JAK1 | |
| SCHEMBL16245166 | 0.86 | JAK3 (0.58) | JAK3JAK2JAK1 | |
| SCHEMBL20184482 | 0.86 | JAK3 (0.44) | JAK3JAK2JAK1 | |
| SCHEMBL20184584 | 0.86 | JAK3 (0.59) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |