SCHEMBL20184759

SCHEMBL20184759

C(=C/c1cc2ccc(C3=NCCN3)cc2[nH]1)\c1ccc(C2=NCCN2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PRMT1 Q99873 11/20 1.00
▸ NISCH Q9Y2I1 2/20 0.49
▸ PRMT3 O60678 1/20 0.48
▸ EHMT2 Q96KQ7 1/20 0.48
▸ PRMT6 Q96LA8 1/20 0.48
▸ PRMT8 Q9NR22 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8235649 0.93 PRMT1 (1.00) PRMT1NISCHPRMT3EHMT2PRMT6
SCHEMBL8238362 0.93 PRMT1 (1.00) PRMT1NISCH
SCHEMBL20184762 0.90 PRMT1 (0.81) PRMT1NISCH
SCHEMBL8235616 0.89 PRMT1 (0.80) PRMT1PRMT3EHMT2PRMT6PRMT8
SCHEMBL20184764 0.81 PRMT1 (1.00) PRMT1NISCHPRMT3EHMT2PRMT6
SCHEMBL17086965 0.81 PRMT1 (0.76) PRMT1NISCHPRMT3EHMT2PRMT6
SCHEMBL9575289 0.80 PRMT1 (0.64) PRMT1NISCH
SCHEMBL13204597 0.80 PRMT1 (0.69) PRMT1NISCHPRMT3EHMT2PRMT6
SCHEMBL362453 0.78 PRMT1 (0.68) PRMT1NISCHPRMT3EHMT2PRMT6
SCHEMBL8229714 0.78 PRMT1 (0.71) PRMT1NISCHPRMT3EHMT2PRMT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945209-B1 BROAD SPECTRUM ANTIBACTERIAL COMPOUNDS US GOV AS REPRESENTED BY THE SECRETARY OF THE UNITED STATES ARMY AND THE U S ARMY MEDICAL RESEARCH (US) 2018-05-30 — — EP disclosed
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