Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | NPFFR1 | Q9GZQ6 | 6/20 | 0.50 |
| ▸ | NPFFR2 | Q9Y5X5 | 6/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187134 | 0.87 | CYP2D6 (0.58) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 | |
| SCHEMBL18353752 | 0.87 | CYP2D6 (0.58) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 | |
| SCHEMBL16876704 | 0.85 | CYP2D6 (0.59) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 | |
| SCHEMBL5556286 | 0.85 | ALDH1A1 (0.61) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 | |
| SCHEMBL16876688 | 0.85 | ALDH1A1 (0.56) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 | |
| SCHEMBL16876691 | 0.84 | CYP2D6 (0.58) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 | |
| SCHEMBL654357 | 0.84 | ALDH1A1 (0.62) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 | |
| SCHEMBL2996293 | 0.84 | CYP2D6 (0.68) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 | |
| SCHEMBL16876740 | 0.83 | CYP2D6 (0.60) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 | |
| SCHEMBL16876730 | 0.81 | CYP2D6 (0.57) | ALDH1A1CYP2D6NPFFR1NPFFR2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849044-B | Triaza-spirodecanones as DDR1 inhibitors | 豪夫迈·罗氏有限公司 | 2021-06-25 | — | — | CN | disclosed |
| EP-3317279-B1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-27 | — | — | EP | disclosed |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2019-10-08 | — | — | US | disclosed |
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2019-06-06 | — | — | US | disclosed |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | HOFFMAN LA-ROCHE INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | HOFFMANN LA-ROCHE INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190169189-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | ALDH1A1 1320/4885CYP2D6 3278/4885NPFFR1 3034/4885 |
| US-20180148450-A1 | TRIAZA-SPIRODECANONES AS DDR1 INHIBITORS | DDR1, DDR2, DDRGK1 | ALDH1A1 1320/4885CYP2D6 3278/4885NPFFR1 3034/4885 |
| US-10435407-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | ALDH1A1 1320/4885CYP2D6 3278/4885NPFFR1 3034/4885 |
| US-10239876-B2 | Triaza-spirodecanones as DDR1 inhibitors | DDR1, DDR2, DDRGK1 | ALDH1A1 1320/4885CYP2D6 3278/4885NPFFR1 3034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.